It is what is known as an "INERT" gas. Radon is soley driven by pressure, (positive or negative) and has absolutely no static charge, therefore, it doesn't stick to anything, so radon cannot be filtered out of the air using conventional methods like single room or whole house air filtration, including even the best HEPA filtration systems.
In most cases, the second method mentioned is the preferred method of chioce. It is known as "active sub-slab depressurization".
Normally, a 3 inch PVC pipe is inserted into the concrete slab in a strategic and preferably non-intrusive spot. The vent pipe is then routed either externally, or, if the floor plan permits, internally through the home's interior, to above the roof edge (away from doors and windows), preventing the gas from re-entering the occupied living area. There, the radon gas can be vented safely to atmosphere, where it will do no harm in its diluted state.
The system is powered by a fan that is specifically designed for use in this application. It is traditionally mounted to an externally routed vent pipe, outdoors, at the rim joist level, or in the attic area, when the venting system is routed internally.
According to proper radon proficiency protocol, RADON SUCTION FANS CANNOT BE INSTALLED EITHER WITHIN OR BENEATH THE "CONDITIONED" ENVELOPE OF THE BUILDING.